FUNCTIONAL-DNA-NANO-BIO-LAB

Education

PHD: NEW YORK UNIVERSITY USA

POST DOC: SIMON FRASER UNIVERSITY, BC, CANADA

ALEXANDER VON HUMBOLDT POST DOC: RWTH, AACHEN, GERMANY

Experience

DBT RAMALINGASWAMI FELLOW, CHEM ENGG, IISC, BANGALORE

Research Interests

• Controlled translocation through nanopore using DNA origami & solid state nanopore hybrid devices 
• DNA aptamer based biosensors for parallel detection of orthogonal targets
• Mimicking membrane dynamics using DNA origami based substrate and channels
• Electrochemistry of DNA nanostructure to understand long distance charge transport and for sensing 
• DNA nanotube metallisation to magnetically control targeted delivery vehicle in vivo.+

Research Area

• DNA Origami
• DNA aptamers
• Hybrid nanopores
• DNA nanostructure based electrochemistry

Selected Publications

• Aptamer-DNA Origami-Functionalized Solid-State Nanopores for Single-Molecule Sensing of G-Quadruplex Formation; S. Pal, A. Naik, A. Rao, B. Chakraborty, and M. M. Varma; ACS Appl. Nano Mater. 2022, 5, 7, 8804–8810 (2022).  

• Aptamers for viral detection and inhibition; B. Chakraborty; S. Das; A. Gupta; Y. Xiong; T V, Vyshnavi; M. Kizer; J. Duan; A. R. Chandrasekaran; X. Wang; ACS Infectious Diseases; 8, 4, 667–692 (selected as a Front Cover) (2022).  

• Aptamer-Programmed DNA Nanodevices for Advanced, Targeted Cancer Theranostics; S. Walia, A. R. Chandrasekaran, B. Chakraborty, and D. Bhatia; ACS Appl. Bio Mater. 4, 7, 5392– 5404 (2021).  

• DNA modification and visualization on an origami-based enzyme nano-factory; E. Weinhold & B. Chakraborty; Nanoscale, 13(4):2465-2471 (2021).

• DNA translocation through vertically stacked 2D layers of graphene & hexagonal Boron Nitride heterostructure nanopore; R. Balasubramanian; S. Pal, A. Rao, A. Naik, B. Chakraborty; P. Maiti; M. Varma; ACS Applied Bio Materials; 4, 1, 451–461 (2020). 

• Smartphone-based kanamycin sensing with ratiometric FRET; S. Umrao, Anusha, V. Jain, B. Chakraborty, R. Roy; RSC Adv., 9, 6143 (2019).  

• Protein-induced fluorescence enhancement as aptamer sensing mechanism for thrombin detection; S. Umrao, V. Jain, Anusha, B. Chakraborty and R. Roy; Sensors & Actuators B, 267, 294–301 (2018).  

• Analyte-driven switching of DNA charge transport: de novo creation of electronic sensors for an early lung cancer biomarker; J. Thomas, B. Chakraborty, D. Sen, and H-Z. Yu; J. Am. Chem. Soc.134, 13823−13833 (2012).  

• A programmable transducer self-assembled from DNA; B. Chakraborty, N. Jonoska; N. C. Seeman; Chem. Sci., 3, 168–176 (2012).  

• The label-free unambiguous detection and symbolic display of single nucleotide polymorphisms on DNA origami; H. K. K. Subramanian, B. Chakraborty, R. Sha, N. C. Seeman. Nano Lett. 11, 910–913 (2011). 

• A robust sequence dependent three state DNA nanomechanical device; B. Chakraborty, R.Sha, N.C. Seeman; Proc. Natl. Acad. Sci USA 105, 17245–17249 (2008).